Anna Spreafico, MD, PhD

Dr. Spreafico is Associate Professor at the University of Toronto and Staff Medical Oncologist and Clinician-Investigator in the Department of Medical Oncology and Hematology at the Princess Margaret Cancer Centre University Health Network in Toronto, Canada. Dr. Spreafico previous trainings include: a PhD in translational research in the Program for Evaluation of Targeted Therapies at the University of Colorado, and a subspecialty fellowship in experimental therapeutics, head and neck (HN) cancer, skin/melanoma at the Princess Margaret Cancer Centre, Toronto. Dr. Spreafico is the HN medical oncology disease site lead and Director of the Phase I Drug Development Fellowship at the Princess Margaret Cancer Centre. Dr. Spreafico is a member of the Canadian Cancer Trial Group (CCTG) Head and Neck Disease site Executive Committee. She serves on the US NCI Head and Neck Cancer Steering Committee rare tumor task force, and she is the Co-Chair of the NRG Oncology Recurrent/Metastatic HN Cancer Working Group.

Dr. Spreafico's full-time academic practice and research include early phase clinical trials, with disease-specific interests in skin/melanoma, and head and neck cancers. Her translational research focuses on immuno-oncology-based, microbiome and cancer interception-driven studies. Dr. Spreafico leads as PI Canadian Cancer Trial Group, NRG and NCI CTEP early phase investigator-initiated clinical trials. She is the recipient of several national and international awards and has published multiple peer-reviewed publications in widely cited journals. Dr. Spreafico developed, launched and continues to direct ARTES, a leadership course to provide education and coaching of soft skills to early career investigators across North America Institutions within multiple US NCI UM1 Consortia sites. Annually, the ARTES course continues to successfully graduate 16-18 international early career investigators within medical, radiation and surgical oncology disciplines.

 

From a translational research aspect, Dr. Spreafico has extensive experience in clinical trial design with a focus on immune-oncology, biomarker-driven investigator-initiated studies that incorporate relevant correlative studies to evaluate mechanisms of antitumour activity and resistance.

Precision medicine and experimental therapeutics to develop new anticancer strategies to increase disease control and cure rates. This includes several investigator-initiated studies of novel agents and/or combinations, particularly in the immune-oncology field. As an example, Dr. Spreafico is the Co-Chair of the international prospective, curative intent, chemo-sparing approach, Canadian-led HN.9 trial, in patients with human papilloma virus-related squamous cell carcinoma of the oropharynx. Through ongoing collaboration with the US National Cancer Institute, she develops and leads heavy biomarker-driven, immunotherapy-based early phase clinical trials.

Biomarker discovery with a particular focus on microbiome and cancer interception studies in immuno-oncology. Dr. Spreafico has established active intra and extra-mural collaborations with microbiome experts and leads observational and interventional studies, with first-in-human novel agents, to evaluate the role of the oral and intestinal microbiome in head and neck and cancer patients receiving chemo-radiation and immune-radiation as well as patients with advanced solid tumours undergoing immunotherapy. Dr. Spreafico's research expands with intra and extramural funding to prospectively analyze intestinal microbiome and autoimmune cytokine panels to predict immune-mediated toxicity in patients undergoing immunotherapy, and cancer-interception trials in patients with resected melanoma who are at high risk of relapse to identify predictive biomarker of responsiveness to guide clinical decision-making.

Research supervision and mentorship of next generation of translational researchers. Dr. Spreafico serves as director of the Drug Development Program Fellowship at the Princess Margaret Cancer Centre. In collaboration with the North America Star Consortium and within the US National Cancer Institute Experimental Therapeutics Clinical Trials Network, Dr. Spreafico is developing a leadership training course for early career investigators to help provide a solid foundation of soft skills needed for a successful research career.

For a list of Dr. Spreafico's publications, please visit PubMed or Scopus.