https://orcid.org/0000-0002-4389-0993Osteoarthritis (OA) represents a major cause of morbidity and disability. Unfortunately, effective OA therapy remains a significant challenge. OA heterogeneity may be contributing to the overall ineffectiveness of symptom treatment and our inability so far to develop disease-modifying drugs for this highly prevalent condition. With a focus on identifying clinically and epidemiologically distinct ‘phenotypes’ in OA, my research has three inter-related themes with common threads of sex differences and inflammation: 1. OA and multijoint involvement; 2. OA, comorbidity and multijoint involvement; and 3. OA and pain. Current work includes clinical and population-based studies. I also undertake epidemiological population-based arthritis work to document and study individual and population-level arthritis burden.