Work in my laboratory is focused on: (i) the development of powerful mass spectrometry (MS)-based techniques to identify and characterize protein-protein interactions and post-translational modifications (PTMs); (ii) using these techniques to better understand fusion proteins implicated in cancers, and the ubiquitin (Ub) and ubiquitin-like protein (Ubl) systems (e.g. SUMO, UFM1, NEDD8, etc.); and (iii) working with a number of excellent collaborators to better characterize individual proteins, protein complexes and (membrane-bound and membrane-less) organelles.