In animals, including humans, scent-based chemical signals—called chemosignals—related to emotions like fear or stress, can influence how others perceive and respond to their surroundings. Researchers at Krembil Brain Institute, in collaboration with the Université de Bordeaux, have uncovered how these signals from stressed individuals may impact memory in others.
Changes in how chemosignals are processed have been found in conditions like autism spectrum disorder. Previous studies in experimental models showed that chemosignals from stressed individuals could alter brain physiology and signalling in non-stressed individuals. However, until now, it was unclear whether these signals also affect memory and cognition.
In this study, led by co-senior author Dr. Jaideep Bains, Senior Scientist and Director at Krembil Research Institute, looked at how stress signals detected through smell cause behavioural adaptations and affect memory in experimental models. Interestingly, the team found that receiving stress signals from another individual impaired memory retrieval.
Using genetic techniques and imaging, the researchers discovered that stress signals rely on CB1 receptors in the brain’s olfactory bulb—a region that processes smells. These receptors, located on the mitochondria of brain cells called astrocytes, trigger calcium movement in these cells which is necessary for detecting stress signals and impacting memory.
These findings suggest that scent-based signals can connect emotional stress with memory function. This could have implications for conditions like autism, where processing such signals is often affected.
Co-senior authors of this study are Dr. Jaideep Bains, Senior Scientist and Director at Krembil Research Institute as well as Dr. Giovanni Marsicano from the Université de Bordeaux.
The first author of this study is Dr. Paula Gómez-Sotres from the Université de Bordeaux.
This work was supported by the The Institut national de la santé et de la recherche médicale, Fondation pour la Recherche Medicale, the Human Frontiers Science Program, French State/Agence Nationale de la Recherche, the Université de Bordeaux, La Caixa Research, the Basque Government, Atención Primaria, Cronicidad y Promoción de la Salud, Red de Investigación en Atención Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III, the France Canada Research Foundation, the Canadian Institutes of Health Research, and UHN Foundation.
Gómez-Sotres P, Skupio U, Dalla Tor T, Julio-Kalajzic F, Cannich A, Gisquet D, Bonilla-Del Rio I, Drago F, Puente N, Grandes P, Bellocchio L, Busquets-Garcia A, Bains JS, Marsicano G. Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice. Nat Commun. 2024 Aug 18;15(1):7103. doi: 10.1038/s41467-024-51416-4.